the anti-apoptotic gene bcl-2 is located in mitochondria, but it is uncertain whether its expression affects hepatocyte survival in ischemia/reperfusion (i/r) injury. this experiment was designed to evaluate the role of folic acid in expression of bcl-2 in i/r in rat liver. eighteen wister rats were divided into sham-operated controlgroup (c) (n=6), i/r group (n=6), folic acid treated group whi...

3,4- Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a psychoactive and hallucinogenic drug of abuse. MDMA has been shown to produce neurotoxicity both in animals and humans. Recently, the vasodilator drugs such as pentoxifylline is one of the new strategies which have been considered as neuroprotector. In this study effect of pentoxifylline on bcl-2 gene expression changes in hippocampus ...

ischemia-reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. twenty–four male wistar rats (250-300 g body wt) were used in this study. the animals were divided into four groups of 6 rat...

3,4- Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a psychoactive and hallucinogenic drug of abuse. MDMA has been shown to produce neurotoxicity both in animals and humans. Recently, the vasodilator drugs such as pentoxifylline is one of the new strategies which have been considered as neuroprotector. In this study effect of pentoxifylline on bcl-2 gene expression changes in hippocampus ...

Ischemia-reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. Ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. Twenty–four male Wistar rats (250-300 g body wt) were used in this study. The animals were divided into four groups of 6 rat...

Ischemia-reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. Ischemia-reperfusion brain injury initiates an inflammatory response involving the expression of adhesion molecules and cytokines. Twenty–four male Wistar rats (250-300 g body wt) were used in this study. The animals were divided into four groups of 6 rat...

introduction: ghrelin is an endogenous peptide that has diverse functions in the body. one of the newly recognized roles of this peptide is its antiapoptotic effect. however, this function has not been investigated in normobaric hypoxia- induced apoptosis in body organs. this study will examine the effect of ghrelin treatment on bax-bcl-2 gene expression in the kidney of chronic hypoxic rats. m...

Introduction: Ghrelin is an endogenous peptide that has diverse functions in the body. One of the newly recognized roles of this peptide is its antiapoptotic effect. However, this function has not been investigated in normobaric hypoxia- induced apoptosis in body organs. This study will examine the effect of ghrelin treatment on Bax-Bcl-2 gene expression in the kidney of chronic hypoxic rats. ...

Introduction: The increasing use of electromagnetic field generators in our daily life in one hand and on contradictory reports on the effects of their waves on public health on the other hand encourages scientists to do more and more research work in this field. One of the most important topics is the study of gene defect due to microwave radiation. Materials and Met...

background and objective: clinical behavior of basal cell carcinoma (bcc) is known to be different according to histological growth pattern and basosquamous cell carcinomas (bsc) are known with their aggressive behavior and metastatic capacity. in this study, we evaluated bcl-2 and cyclin d1 expressions in bcc and bsc cases comparatively, to explore their predictive value on the aggressive beha...